Thursday, September 8, 2011

Definition of Agranulocytosis

Definition of Agranulocytosis

Agranulocytosis /agran·u·lo·cy·to·sis/ (a-gran″u-lo-si-to´sis) a symptom complex characterized by decreased granulocytes and by lesions of the throat, other mucous membranes, gastrointestinal tract, and skin; most cases are complications of drug therapy, radiation, or exposure to chemicals.
(Dorland's Medical Dictionary for Health Consumers. © 2007 by Saunders, an imprint of Elsevier, Inc. All rights reserved.)


An acute disease characterized by high fever, lesions of the mucous membranes and skin, and a sharp drop in circulating granular white blood cells.
(The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.)


An acute condition marked by severe depression of the bone marrow, which produces white blood cells, and by prostration, chills, swollen neck, and sore throat sometimes with local ulceration. Aalso called agranulocytic angina or granulocytopenia.
(Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved)


A severe reduction in the number of leukocytes (basophils, eosinophils, and neutrophils). Neutropenia results, whereby the body is severely depleted in its ability to defend itself. Fever, prostration, and bleeding ulcers of the rectum, mouth, and vagina may be present. The acute disease may be an adverse reaction to a medication or the result of the effect of radiation therapy or chemotherapy on bone marrow.
(Mosby's Medical Dictionary, 8th edition. © 2009, Elsevier)


An acute disease in which there is a dramatic decrease in the production of granulocytes, so that a pronounced neutropenia evolves, leaving the body defenseless against bacterial invasion. A great majority of cases are caused by sensitization to drugs or chemicals that affect the bone marrow and depress the formation of granulocytes. Called also malignant or pernicious leukopenia and idiopathic or malignant neutropenia.
(Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.)




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